When to use SODERMIX®

Side effects of radiotherapy

Radiodermatitis is a frequent side effect occurring in approximately 80% of patients undergoing radiotherapy.

It features cutaneous irritation in the body area under treatment.

It ranges from a slight redness and dryness (similar to sunburn) to intense skin desquamation in certain areas.

It usually appears a few weeks after the end of treatment.

Radiodermatitis is a simple cutaneous inflammation, and it was demonstrated that topical superoxide dismutase (SOD) can be very helpful to alleviate this disorder.

In a study conducted in Madrid (Manzanas, 2008) 57 patients with radiodermatitis were enrolled and applied a SOD cream twice a day. At the end of radiotherapy, 77.1% of patients improved completely or partially, and at the end of the 12-week follow-up 100% of patients got rid of radiodermatitis.


Fibrosis is a late side effect of radiotherapy, occurring in approximately 70% of those patients with head and neckcancer and 25% of women treated with radiation for breast cancer, 5% of them in a painful form.

It can take months or years to develop after a course of treatment.

Fibrosis features the formation of a scarring tissue in the irradiated area, which becomes stiffened and in areas such as the neck, besides its unaesthetic appearrance, it can limit the movement and get very uncomfortable.

The role of free radicals is of utmost importance in the occurrence of fibrosis, and consequently antioxidants may result efficient in its treatment and even in its reversion.

Various studies performed at Institut Curie in Paris have found topical SOD to be helpful in the treatment of fibrosis post-irradiation, when applied twice a day during at least 3 months.

According to the authors, improvement was observed in 74% (Benyahia, 1996) to 80% of patients (Campana, 2004) and pain was reduced in 90% of patients.