When to use SODERMIX®

Keloid and Hypertrophic Scars

A keloid is an overgrowth of dense fibrous tissue that usually develops after healing of a skin injury. The tissue extends beyond the borders of the original wounds, usually does not regress spontaneously and tends to recur after excision.

Meanwhile, HS remain limited to the traumatized area and regress spontaneously within 12-18 months, although regression may not necessarily be complete.

Keloids and HS located at most sites primarily are of cosmetic concern; however, some keloids or HS can cause contractures, which may result in a loss of function if overlying a joint or in significant disfigurement if located on the face.

Both keloids and HS can be painful or pruritic.

While unique to humans, keloids usually manifest in pigmented individuals, including Blacks, Hispanics and Asians.

In the Polynesians and the Chinese, keloids form more frequently than in Indians and Malaysians. Whites and albinos are affected least commonly.

The incidence in young female patients has been reported to be higher than in young males, probably reflecting the higher frequency of earlobe piercing among women, although keloids and HS affect both sexes equally in other age groups.

Onset occurs more commonly in individuals aged 10-30 years. Keloids occur less frequently at the extremes of age, although an increasing number of presternal keloids have resulted from coronary artery bypass operations and other similar procedures now undertaken in older age groups.

In white patients, keloids tend to be present, in decreasing order of frequency, on the face (with cheeks and earlobes predominating), upper extremities, chest, presternal area, neck, back, lower extremities, breast and abdomen. (7)

In black subjects, the descending order of frequency tends to be earlobes, face, neck, lower extremities, breast, chest, back and abdomen.

In Asians, the descending order of frequency is earlobes, upper extremities, neck, breast and chest.

Hypertrophic scars and keloids represent a deviation from the fundamental processes of wound healing, which include cell migration and proliferation, inflammation, increased synthesis and secretion of cytokines and extracellular matrix proteins, and remodeling of the newly synthesized matrix.

By reducing the synthesis and secretion of cytokines and extracellular matrix proteins, Superoxide Dismutase (SOD) contained in SODERMIX® permits to:

  • Suppress immediately the pruritus frequently associated with keloid and hyperprophic scars,
  • Reduce in a rapid manner the inflammation, and consequent discoloration of the skin.
  • Along time, permits to flatten, soften and smooth the scars.






SODERMIX® Cream is very simple to apply and should be used twice a day.

Spread a thin coat of SODERMIX® Cream over the affected area, and allow it to penetrate before using regular cream and/or make-up.

Continue to use SODERMIX® Cream until no further benefits are visible; on the contrary consult your physician.

In normal conditions of use, SODERMIX® Cream is showing a remarkable safety of use and tolerability.

Anyhow, it is recommended to take the following precautions:

  • SODERMIX® Cream should not be applied to open wounds.
  • SODERMIX® Cream should be applied on clean and dry skin.
  • If redness, pain or irritation occurs, discontinue use and consult your physician.
  • Keep SODERMIX® Cream out of reach of children. For external use only.